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2021 SfNIRS Virtual Meeting Q&A: Invited talk 2

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CulverJoseph
CulverJoseph(@culverjoseph) (@culverjoseph)
1 month ago

Great talk with great image reconstructions. I think I missed it, but what is the frame rate of your broad band system? And do you have anything different about the temporal processing or is it the same for both oxy/deoxy/cytochrome.

Maheen Siddiqui
Maheen Siddiqui(@maheen-siddiqui91) (@maheen-siddiqui91)
Reply to  CulverJoseph
1 month ago

Thank you, Joe!

The sampling rate was 1 s.

Do you mean did I observe any differences in the chromophores for social/non-social processing? If so, cytochrome (in majority of infants and certainly at the group-level) appeared to be more spatially localised than haemodynamic activity. Hope that answers your question!

CulverJoseph
CulverJoseph(@culverjoseph) (@culverjoseph)
Reply to  Maheen Siddiqui
1 month ago

I was wondering as much about temporal filtering… do you use the same low pass, and high pass filtering for all contrasts? It looks like it, but I’ve never thought through processing for cytochrome… is there a reason for it to be slower or faster…. or how do you think of this?

Guy Perkins
Guy Perkins(@guyperkins) (@guyperkins)
1 month ago

Great talk. With the study and these results, do you have plans for these measurements to give parents information about their child, I.e if a child hadn’t been given an elevated likelihood of autism, would lack of NVC in their measurements make them flagged for autism tests etc.?

Maheen Siddiqui
Maheen Siddiqui(@maheen-siddiqui91) (@maheen-siddiqui91)
Reply to  Guy Perkins
1 month ago

Hi Guy! Thanks, great question. I’m not entirely sure of that to be honest. I studied 42 infants (and had 10 more that were pilots) and in this sample of typically developing infants, I never saw atypical haemodynamic and metabolic coupling. I am, however, going to be doing further work with a larger group of typically developing infants using a range of different experimental paradigms and that will really highlight if these alterations exist in the typical population. And then further work with infants at elevated likelihood for autism should help us understand what these atypical measurements might mean. So if it was to be used as a clinical marker, that will be many years down the line I think! The other thing to consider is that many of the infants that have an elevated likelihood for autism (due to having a sibling with autism) don’t receive an autism diagnosis but kind of fall below the “threshold” for diagnosis. So this kind of work in the future with larger groups of typical and atypical infants will help us identify normal patterns. Long way to go still! Hope that answers your question!

ReRebecca
ReRebecca(@rerebecca) (@rerebecca)
1 month ago

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